Overexpression of ß-Arrestin1 in the Rostral Ventrolateral Medulla Downregulates Angiotensin Receptor and Lowers Blood Pressure in Hypertension
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چکیده
Citation: Sun J-C, Liu B, Zhang R-W, Jiao P-L, Tan X, Wang Y-K and Wang W-Z (2018) Overexpression of ß-Arrestin1 in the Rostral Ventrolateral Medulla Downregulates Angiotensin Receptor and Lowers Blood Pressure in Hypertension. Front. Physiol. 9:297. doi: 10.3389/fphys.2018.00297 Overexpression of ß-Arrestin1 in the Rostral Ventrolateral Medulla Downregulates Angiotensin Receptor and Lowers Blood Pressure in Hypertension
منابع مشابه
Expression of constitutively active angiotensin receptors in the rostral ventrolateral medulla increases blood pressure.
Angiotensin type 1A (AT(1A)) receptors are expressed within the rostral ventrolateral medulla, and microinjections of angiotensin II into this region increase sympathetic vasomotor tone. To determine the effect of sustained increases in AT(1A) receptor density or activity in rostral ventrolateral medulla, we used radiotelemetry to monitor blood pressure in conscious rats before and after bilate...
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